diff --git a/arch/arm/include/nrf53/nrf5340_irq_cpuapp.h b/arch/arm/include/nrf53/nrf5340_irq_cpuapp.h
index 5b0c7820b6f..c9466837bec 100644
--- a/arch/arm/include/nrf53/nrf5340_irq_cpuapp.h
+++ b/arch/arm/include/nrf53/nrf5340_irq_cpuapp.h
@@ -33,11 +33,11 @@
 #define NRF53_IRQ_CACHE         (NRF53_IRQ_EXTINT+1)   /* CACHE interrupt */
 #define NRF53_IRQ_SPU           (NRF53_IRQ_EXTINT+3)   /* SPU interrupt */
 #define NRF53_IRQ_POWER_CLOCK   (NRF53_IRQ_EXTINT+5)   /* Power, Clock, Bprot */
-#define NRF53_IRQ_UART0         (NRF53_IRQ_EXTINT+8)   /* UART/UARTE 0 */
-#define NRF53_IRQ_UART1         (NRF53_IRQ_EXTINT+9)   /* UART/UARTE 1 */
+#define NRF53_IRQ_SERIAL0       (NRF53_IRQ_EXTINT+8)   /* UART/SPI/TWI 0 */
+#define NRF53_IRQ_SERIAL1       (NRF53_IRQ_EXTINT+9)   /* UART/SPI/TWI 1 */
 #define NRF53_IRQ_SPIM4         (NRF53_IRQ_EXTINT+10)  /* SPIM4 */
-#define NRF53_IRQ_UART2         (NRF53_IRQ_EXTINT+11)  /* UART/UARTE 2 */
-#define NRF53_IRQ_UART3         (NRF53_IRQ_EXTINT+12)  /* UART/UARTE 3 */
+#define NRF53_IRQ_SERIAL2       (NRF53_IRQ_EXTINT+11)  /* UART/SPI/TWI 2 */
+#define NRF53_IRQ_SERIAL3       (NRF53_IRQ_EXTINT+12)  /* UART/SPI/TWI 3 */
 #define NRF53_IRQ_GPIOTE0       (NRF53_IRQ_EXTINT+13)  /* GPIO Task & Event 0 */
 #define NRF53_IRQ_SAADC         (NRF53_IRQ_EXTINT+14)  /* Analog to Digital Converter */
 #define NRF53_IRQ_TIMER0        (NRF53_IRQ_EXTINT+15)  /* Timer 0 */
diff --git a/arch/arm/include/nrf53/nrf5340_irq_cpunet.h b/arch/arm/include/nrf53/nrf5340_irq_cpunet.h
index 010b114c760..b2997d74b47 100644
--- a/arch/arm/include/nrf53/nrf5340_irq_cpunet.h
+++ b/arch/arm/include/nrf53/nrf5340_irq_cpunet.h
@@ -40,7 +40,7 @@
 #define NRF53_IRQ_TEMP          (NRF53_IRQ_EXTINT+16)  /* Temperature Sensor */
 #define NRF53_IRQ_RTC0          (NRF53_IRQ_EXTINT+17)  /* Real-time counter 0 */
 #define NRF53_IRQ_IPC           (NRF53_IRQ_EXTINT+18)  /* IPC */
-#define NRF53_IRQ_UART0         (NRF53_IRQ_EXTINT+19)  /* UART/UARTE 0 */
+#define NRF53_IRQ_SERIAL0       (NRF53_IRQ_EXTINT+19)  /* UART/SPI/TWI 0 */
 #define NRF53_IRQ_EGU0          (NRF53_IRQ_EXTINT+20)  /* Event Gen. Unit 0 */
 #define NRF53_IRQ_RTC1          (NRF53_IRQ_EXTINT+22)  /* Real-time counter 1 */
 #define NRF53_IRQ_TIMER1        (NRF53_IRQ_EXTINT+24)  /* Timer 1 */
diff --git a/arch/arm/src/nrf53/nrf53_serial.c b/arch/arm/src/nrf53/nrf53_serial.c
index 1d65981e736..efd8843ca1a 100644
--- a/arch/arm/src/nrf53/nrf53_serial.c
+++ b/arch/arm/src/nrf53/nrf53_serial.c
@@ -166,7 +166,7 @@ static char g_uart1txbuffer[CONFIG_UART1_TXBUFSIZE];
 static struct nrf53_dev_s g_uart0priv =
 {
   .uartbase       = NRF53_UART0_BASE,
-  .irq            = NRF53_IRQ_UART0,
+  .irq            = NRF53_IRQ_SERIAL0,
   .rx_available   = false,
   .config         =
   {
@@ -208,7 +208,7 @@ static uart_dev_t g_uart0port =
 static struct nrf53_dev_s g_uart1priv =
 {
   .uartbase       = NRF53_UART1_BASE,
-  .irq            = NRF53_IRQ_UART1,
+  .irq            = NRF53_IRQ_SERIAL1,
   .rx_available   = false,
   .config         =
   {