diff --git a/arch/arm/src/stm32l0/stm32l0_rcc.c b/arch/arm/src/stm32l0/stm32l0_rcc.c
index 10f32d300bb..3fa846122c3 100644
--- a/arch/arm/src/stm32l0/stm32l0_rcc.c
+++ b/arch/arm/src/stm32l0/stm32l0_rcc.c
@@ -319,7 +319,9 @@ static inline void rcc_enableapb2(void)
 
   regval = getreg32(STM32_RCC_APB2ENR);
 
-#ifdef CONFIG_STM32_SYSCFG
+  /* VREFINT is configured through SYSCFG_CFGR3, so its clock is required */
+
+#if defined(CONFIG_STM32_SYSCFG) || defined(CONFIG_STM32_VREFINT)
   /* SYSCFG clock */
 
   regval |= RCC_APB2ENR_SYSCFGEN;